Table 1.

Relative risk of the diagnosis of specific malignancies following a diagnosis of breast cancer in the SEER database

Site	15–49 years RR (95% CI)	P-value	50–64 years RR (95% CI)	P-value	65 years plus RR (95% CI)	P-value
AML	4.14 (2.70–6.35)	<0.001	2.19 (1.68–2.85)	<0.001	1.19 (0.95–1.49)	0.123
Breast	2.53 (2.40–2.68)	<0.001	1.46 (1.40–1.52	<0.001	1.25 (1.20–1.30)	<0.001
Ovarian	2.29 (1.92–2.73)	<0.001	1.25 (1.11–1.41)	<0.001	0.93 (0.82–1.05)	0.250
ALL	1.60 (0.47–5.48)	0.553	1.13 (0.43–2.92)	0.808	0.80 (0.34–1.88)	0.602
CLL	1.15 (0.65–2.03)	0.633	0.85 (0.64–1.13)	0.270	0.60 (0.47–0.75)	<0.001
CML	1.41 (0.67–2.95)	0.359	1.06 (0.66–1.69)	0.811	1.09 (0.78–1.51)	0.617
Lymphoma	0.93 (0.74–1.17)	0.542	0.87 (0.76–0.99)	0.038	0.88 (0.79–0.98)	0.019
Myeloma	0.87 (0.54–1.39)	0.550	0.85 (0.67–1.07)	0.170	0.97 (0.82–1.15)	0.724
Lung	1.37 (1.22–1.54)	<0.001	1.01 (0.94–1.07)	0.857	0.82 (0.77–0.87)	<0.001
Uterine	1.30 (1.12–1.51)	<0.001	1.22 (1.12–1.33)	<0.001	1.51 (1.39–1.64)	<0.001
Cervical	0.62 (0.46–0.82)	0.001	0.56 (0.44–0.71)	<0.001	0.69 (0.55–0.88)	0.002
Bladder	1.44 (1.08–1.94)	0.014	1.11 (0.96–1.29)	0.165	0.97 (0.86–1.08)	0.555
Gastric (stomach)	1.55 (1.04–2.31)	0.031	1.21 (0.98–1.48)	0.078	1.05 (0.91–1.21)	0.517
Bones and joints	2.53 (0.91–7.02)	0.065	0.97 (0.43–2.16)	0.932	0.97 (0.43–2.15)	0.931
Esophageal	1.63 (0.90–2.94)	0.104	1.46 (1.09–1.96)	0.011	1.20 (0.94–1.53)	0.138
Oral cavity	1.25 (0.92–1.68)	0.151	1.09 (0.91–1.31)	0.327	1.00 (0.85–1.18)	0.981
Thyroid	1.19 (0.92–1.54)	0.180	1.21 (0.95–1.53)	0.116	1.20 (0.91–1.58)	0.189
Pancreatic	1.16 (0.84–1.59)	0.380	0.93 (0.80–1.09)	0.377	0.83 (0.74–0.93)	0.001
Kidney	0.95 (0.69–1.30)	0.734	1.00 (0.84–1.20)	1.00	1.11 (0.95–1.29)	0.199
Colorectal	0.99 (0.86–1.15)	0.929	1.02 (0.95–1.10)	0.516	1.01 (0.96–1.06)	0.761
All	1.70 (1.64–1.76)	<0.001	1.07 (1.04–1.09)	<0.001	0.92 (0.90–0.94)	<0.001

RR relative risk, NHL non-hodgkin lymphoma, CI confidence interval, ALL acute lymphoblastic leukemia