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SULT1A1*1/*2 (638G > A) influence on the sulfation of fulvestrant (4A) and β-naphthol (4B). Enzymatic activity was determined either colorimetrically (for β-naphthol) or by LC-MS/MS. Genotype–phenotype relationships were assessed by analysis of variance with phenotype as the dependent variable.
Abbreviation: LC-MS/MS, liquid chromatography–mass spectrometry/tandem mass spectrometry.
