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. 2012 Jul 9;2012:857510. doi: 10.1155/2012/857510

Table 3.

Odds ratios (ORs) of colon cancer for changes in BMI over time by age, decadesa.

All postmenopausal women Postmenopausal women with no HRT Postmenopausal women with HRT
kg/m2 Case/control OR P P* Case/control OR P P* Case/control OR P P*
Change in BMI in 50s <5 (ref)c 366/691 1.00 189/259 1.00 177/432 1.00
5–10 57/91 0.92 (0.61–1.40) 0.71 42/42 1.15 (0.66–1.99) 0.62 15/49 0.67 (0.17–2.65) 0.42
>10 12/23 0.62 (0.27–1.43) 0.26 0.47 9/11 0.72 (0.24–2.16) 0.56 0.90 3/12 1.02 (0.66–1.58) 0.57 0.47
Change in BMI in 40s <5 (ref) 286/587 1.00 142/208 1.00 144/379 1.00
5–10 105/192 0.90 (0.64–1.26) 0.55 63/85 0.86 (0.53–1.40) 0.54 42/107 0.93 (0.56–1.52) 0.76
>10 35/51 0.98 (0.57–1.69) 0.95 0.88 23/28 0.82 (0.39–1.70) 0.59 0.59 12/23 1.24 (0.54–2.86) 0.62 0.65
Change in BMI in 30s <5 (ref) 197/473 1.00 94/171 1.00 103/302 1.00
5–10 158/256 1.48 (1.06–2.07) 0.02 94/98 1.91 (1.16–3.17) 0.01 64/158 1.22 (0.76–1.95) 0.41
>10 72/109 1.51 (0.94–2.43) 0.09 0.02 44/50 1.79 (0.90–3.55) 0.10 0.0498 28/59 1.57 (0.79–3.12) 0.20 0.10
Change in BMI in 20s <5 (ref) 152/368 1.00 77/138 1.00 75/230 1.00
5–10 182/313 1.54 (1.09–2.19) 0.02 91/110 1.77 (1.02–3.05) 0.04 91/203 1.41 (0.88–2.27) 0.16
>10 122/185 1.45 (0.90–2.33) 0.12 0.049 83/81 2.21 (1.09–4.45) 0.03 0.02 39/104 1.11 (0.56–2.19) 0.76 0.38

aAdjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, family history of colorectal cancer, age at menarche, and parity. Analysis additionally adjusted for baseline BMI (BMI in the “recruitment period,” 2 years before recruitment). c<5 kg/m2 (weight gain of approximately <25 lbs); 5–10 kg/m2 (weight gain of ~25–50 lbs) and >10 kg/m2 (weight gain exceeding 50 lbs). P value for trend.