Table 3.
Odds ratios (ORs) of colon cancer for changes in BMI over time by age, decadesa.
All postmenopausal women | Postmenopausal women with no HRT | Postmenopausal women with HRT | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
kg/m2 | Case/control | OR | P | P* | Case/control | OR | P | P* | Case/control | OR | P | P* | |
Change in BMI in 50s | <5 (ref)c | 366/691 | 1.00 | — | — | 189/259 | 1.00 | — | — | 177/432 | 1.00 | — | — |
5–10 | 57/91 | 0.92 (0.61–1.40) | 0.71 | — | 42/42 | 1.15 (0.66–1.99) | 0.62 | — | 15/49 | 0.67 (0.17–2.65) | 0.42 | — | |
>10 | 12/23 | 0.62 (0.27–1.43) | 0.26 | 0.47 | 9/11 | 0.72 (0.24–2.16) | 0.56 | 0.90 | 3/12 | 1.02 (0.66–1.58) | 0.57 | 0.47 | |
Change in BMI in 40s | <5 (ref) | 286/587 | 1.00 | — | — | 142/208 | 1.00 | — | — | 144/379 | 1.00 | — | — |
5–10 | 105/192 | 0.90 (0.64–1.26) | 0.55 | — | 63/85 | 0.86 (0.53–1.40) | 0.54 | — | 42/107 | 0.93 (0.56–1.52) | 0.76 | — | |
>10 | 35/51 | 0.98 (0.57–1.69) | 0.95 | 0.88 | 23/28 | 0.82 (0.39–1.70) | 0.59 | 0.59 | 12/23 | 1.24 (0.54–2.86) | 0.62 | 0.65 | |
Change in BMI in 30s | <5 (ref) | 197/473 | 1.00 | — | — | 94/171 | 1.00 | — | — | 103/302 | 1.00 | — | — |
5–10 | 158/256 | 1.48 (1.06–2.07) | 0.02 | — | 94/98 | 1.91 (1.16–3.17) | 0.01 | — | 64/158 | 1.22 (0.76–1.95) | 0.41 | — | |
>10 | 72/109 | 1.51 (0.94–2.43) | 0.09 | 0.02 | 44/50 | 1.79 (0.90–3.55) | 0.10 | 0.0498 | 28/59 | 1.57 (0.79–3.12) | 0.20 | 0.10 | |
Change in BMI in 20s | <5 (ref) | 152/368 | 1.00 | — | — | 77/138 | 1.00 | — | — | 75/230 | 1.00 | — | — |
5–10 | 182/313 | 1.54 (1.09–2.19) | 0.02 | — | 91/110 | 1.77 (1.02–3.05) | 0.04 | — | 91/203 | 1.41 (0.88–2.27) | 0.16 | — | |
>10 | 122/185 | 1.45 (0.90–2.33) | 0.12 | 0.049 | 83/81 | 2.21 (1.09–4.45) | 0.03 | 0.02 | 39/104 | 1.11 (0.56–2.19) | 0.76 | 0.38 |
aAdjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, family history of colorectal cancer, age at menarche, and parity. Analysis additionally adjusted for baseline BMI (BMI in the “recruitment period,” 2 years before recruitment). c<5 kg/m2 (weight gain of approximately <25 lbs); 5–10 kg/m2 (weight gain of ~25–50 lbs) and >10 kg/m2 (weight gain exceeding 50 lbs). ∗P value for trend.