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. Author manuscript; available in PMC: 2012 Jul 19.
Published in final edited form as: Clin Chem. 2008 May 1;54(7):1190–1196. doi: 10.1373/clinchem.2007.099291

Table 3.

Rate ratio of myocardial infarction and 95% CI by quartile of adrenal hormone concentrations among predominantly postmenopausal women in the Nurses’ Health Study.

Hormone concentration quartile categories P value
for linear trend
1 2 3 4
DHEA, nmol/L <9.60 9.61–16.55 16.56–26.33 ≥26.34
    Cases/controls 58/114 53/112 56/110 62/113
    Model a 1.0 (referent) 0.97 (0.77–1.23) 1.01 (0.79–1.28) 1.05 (0.83–1.34) 0.06
    Model b 1.0 (referent) 0.92 (0.71–1.21) 1.09 (0.82–1.44) 1.19 (0.90–1.57) <0.01
    Model c 1.0 (referent) 0.93 (0.68–1.26) 1.19 (0.87–1.63) 1.27 (0.92–1.74) <0.01
    Model d 1.0 (referent) 0.92 (0.66–1.27) 1.22 (0.88–1.68) 1.23 (0.89–1.72) 0.08
DHEA-S, nmol/L <709 710–1110 1111–1674 ≥1675
    Cases/controls 43/112 61/111 61/108 57/107
    Model a 1.0 (referent) 1.23 (0.96–1.57) 1.23 (0.96–1.58) 1.26 (0.97–1.64) 0.52
    Model b 1.0 (referent) 1.38 (1.04–1.82) 1.46 (1.08–1.96) 1.52 (1.11–2.06) 0.14
    Model c 1.0 (referent) 1.44 (1.05–1.96) 1.56 (1.12–2.17) 1.58 (1.13–2.21) 0.06
    Model d 1.0 (referent) 1.43 (1.01–2.02) 1.60 (1.11–2.31) 1.58 (1.09–2.30) 0.14

Data are RR (95% CI). Model a, Conditional logistic regression model controlling for matching factors only; model b, conditional logistic regression additionally controlling for age at blood draw (as a linear continuous variable), time of blood collection (1201–0700, 0701–1100, 1101–1200), fasting status at blood collection (fasting for ≥10 h vs <10 h or unknown), menopausal status (postmenopausal, uncertain status vs premenopausal), parents’ history of myocardial infarction, current postmenopausal hormone use, aspirin use, mean alcohol intake, body mass index, and physical activity in MET-hours (the latter 3 variables modeled as continuous variables with natural cubic splines); model c, conditional logistic regression additionally controlling for history of diabetes, history of hypertension, and history of hypercholesterolemia; model d, conditional logistic regression additionally controlling for plasma CRP and total-to-HDL cholesterol ratio (both modeled as continuous variables with natural cubic splines).

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