Figure 7.

Involvement of FPRs in the PMN-induced mobilization of inflammatory monocytes. (A) Extravasation of Gr1⁺ inflammatory monocytes in the air pouch of neutropenic mice (PMN depl) after stimulation with PAF combined with PMN secretion or individual granule proteins. ▨ indicate pretreatment with the FPR antagonist BOC-PLPLP. * indicates significant difference compared with respective treatment in the absence of the fpr antagonist. (B) Ca²⁺ mobilization in inflammatory monocytes in response to PMN secretion or individual granule proteins. Ca²⁺ mobilization was measured in the FACS in the presence or absence of the FPR antagonist BOC-PLPLP. * indicates significant difference compared with respective treatment in the absence of the fpr antagonist.