. Author manuscript; available in PMC: 2012 Jul 25.

Published in final edited form as: Clin Pharmacol Ther. 2011 Dec 28;91(2):234–242. doi: 10.1038/clpt.2011.216

Table 1.

Pharmacokinetic parameter estimates of somatropin (standard errors) from the three-way crossover trial (complete dataset)

	t_lag (h)	k_a (h⁻¹)	V/F (L)	CL/F (L/h)	corr_CL-V
μ_R	0.49 (0.07)	0.32 (0.07)	26.22 (0.1)	8.63 (0.03)
β_T₁	−0.22 (0.07)	−0.2 (0.07)	−0.12 (0.1)	0.01 (0.03)
β_T₂	−0.07 (0.06)	−0.06 (0.08)	0.07 (0.11)	0.05 (0.03)
BSV	0.33 (0.05)	0.18 (0.04)	0.44 (0.04)	0.23 (0.02)	0.81
WSV	0.09 (0.04)	0.19 (0.03)	0.26 (0.03)	0.1 (0.01)	0.49
a (ng/mL)	0.11 (0.02)
b	0.14 (0.004)

Period and sequence effects are not reported. a, additive error model parameter; b, proportional error model parameter; BSV, standard deviation for between-subject variability; β_T₁, formulation effect for the test formulation T₁; β_T₂, formulation effect for the test formulation T₂; corr_CL-V, correlation between CL/F and V/F; μ_R, fixed effects for the formulation of reference; WSV, standard deviation for within-subject variability.