. Author manuscript; available in PMC: 2012 Jul 25.

Published in final edited form as: Clin Pharmacol Ther. 2011 Dec 28;91(2):234–242. doi: 10.1038/clpt.2011.216

Table 3.

Pharmacokinetic parameter estimates of epoetin alpha (standard errors) from the parallel group trial

	V_c (L)	V_p (L)	CL_lin (L/h)	Q (L/h)	V_max (IU/h)	K_m (IU/L)	C₀ (IU/L)	corr _{CL_lin}₋ _{V_c}
μ_R	4.05 (0.14)	2.58 (0.46)	0.36 (0.06)	0.34 (0.06)	341.22 (38.09)	90.83 (17.74)	8.26 (0.34)
β_T	0.06 (0.05)	0.17 (0.23)	0.17 (0.23)	0.20 (0.21)	−0.07 (0.16)	−0.16 (0.28)	0.06 (0.06)
BSV	0.21 (0.01)	0.16 (0.04)	0.34 (0.02)	0.13 (0.05)	0.13 (0.03)	0.39 (0.05)	0.25 (0.02)	0.9 (/)

b	0.15 (0.003)

b, proportional error model parameter; BSV, standard deviation for the between-subject variability; β_T, formulation effect for the test formulation; corr_{CL_lin}₋_{V_c}, correlation between CL_lin and V_c; μ_R, fixed effects for the formulation of reference