Table 1. Clinical signs and virus replication in inoculated ferrets.
| Viruses | Clinical signs | Virus titer (log10 pfu/ml)b | ||||
| Weight loss No/total (mean a max. % loss) | Sneezing (No/total) | Nasal turbinates | Trachea upper | Trachea lower | Lungc | |
| Eurasian avian like swine: | ||||||
| A/sw/Italy/3169-7/1994 (H1N1) | 1/4 (5) | 0/4 | –, – | –, 5.3 | –, 4.5 | 3.3, 4.6 |
| TRS with sw-like HA and NA | ||||||
| A/sw/NC/47834/2000 (H1N1) | 2/4 (5) | 0/4 | 4.6, 4.7 | 3.7, 2.8 | 3.2, 2.3 | 3.5, 2.9 |
| A/sw/NC/18161/2002 (H1N1) | 2/4 (9) | 1/4 | 4.6, – | 3.5, – | 2.8, 1.7 | 3.5, 2.6 |
| A/sw/MN/6998/03 (H1N1) | 2/4 (6) | 1/4 | 2.9, 3.9 | 4.8, 4.5 | 4.9, 5.0 | 6.0, 2.6 |
| TRS with sw-like HA and hu-like NA | ||||||
| A/sw/IN/9K035/99 (H1N2) | 3/4 (5) | 2/4 | 4.7, 5.1 | 2.6, 5.3 | 3.8, 4.2 | 5.3, 5.3 |
| A/sw/MN/1192/01 (H1N2) | 2/4 (9) | 2/4 | 4.5, 1.3 | 5.6, 4.1 | 4.7, 5.5 | 1.8, 6.0 |
| A/sw/MN/5763/03 (H1N2) | 1/4 (3) | 1/4 | 5.0, 4.7 | 4.5, 2.6 | 3.8, 2.8 | 3.5, 2.3 |
| TRS with hu-like HA and NA | ||||||
| A/sw/NC/38448-1/2005 (H1N1) | 1/4 (5) | 1/4 | 5.7, 2.9 | 4.8, 3.2 | 4.3, 3.8 | 5.2, 4.7 |
| A/sw/OK/011521-5/2008 (H1N2) | 2/4 (5) | 2/4 | 5.3, – | 5.7, 6.3 | 6.0, 5.8 | 5.1, 5.8 |
| A/sw/OK/011506/2007 (H3N2) | 1/4 (7) | 0/4 | 5.1, 4.8 | 4.2, 2.9 | 4.5, 2.8 | 5.1, 3.7 |
Sw, swine; hu, human.
–, Below the limit of detection (1.3 log10 pfu/ml).
a
Mean (when multiple ferrets lost weight) percent maximum weight loss (ferrets not showing weight loss were excluded from this calculation).
b
Values derived from two ferrets.
c
Homogenates combining portions of all six lobes.