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. 2012 Jul 19;7(7):e41204. doi: 10.1371/journal.pone.0041204

Table 2. Functional classification of the TBDT sequences extracted from NR and the GOS datasets.

Function categories Lek Cluster number TBDT* Substrates NCBI sequences GOS peptides
Group I: DOM transporters Cluster 3090 Sden_2708(91794059), CPS_1021(71281574), PSPTO_3242(28870407), XCC2385(21231822), MalA(220964479), XCC2469(21231904), MalA(16126526), NagA(13421615), XCC2828(21232259), SO_3514(24375018), CC_0446(16124701), XCC0120(21229598), XCC2944(21232375), XCC4120(21233542) XCC2887(21232318) Chito-oligosaccharides, phytate, maltodextrin, maltose, chitin, xylan, xylose, pectin 816 3107
Cluster 720 RagA(110636966, 110636973),SusC(29349110), CsuF(29348741) Digested proteins, starch/malto-oligo-saccharides, chondroitin sulfate/hyaluronic acid 3565 2060
Cluster 427 XCC4222(21233639) Arabinose 945 5748
Cluster 952 SuxA(21232787), Sfri_3988(114565138) Sucrose 53 4
Group II: Siderophores/Vitamins transporters Cluster 3303 FecA(729471, 16132112) Ferric-citrate 288 946
Cluster 410 FmtA(53719389), PupA(45723), FatA(132510), FcuA(1169655), ViuA(267356), RhtA(6685883), BfrI(33592999), Bcep18194_b2436(78063283), PupB(585759), IutA(84060860), SftP(6019468), XCC0674(21230149), CPS_0067(71281279), FhuE(16129065), PbuA(1172035), FpvA(12230910), FauA(4589285), FhuE(2507465), FptA(1169730), SO_2715(24374256), PhuR(3044098), PrhA(17549099), IutA(1170593),FctA(871032), BfrZ(6850914), FyuA(517234),BauA(49175779), Fiu(170080464), FhuA(16128143), VciA(147673813), PiuA_Fiu(115587765), FoxA(1169726), FegA(1518696),FhuA(2507464), OptS(116050410), IrpC(17380443), OrbA(76810798) Aerobactin, alcaligin, anguibactin, catecholates, chrysobactin, coprogen, ferrioxamine B, rhodoturolic acid, desferrioxamine, ferric malleobactin, ferric ornibactin, ferrichrome, hexylsulfate, pseudobactin A, pseudobactin M114, pyochelin, pyoverdine, rhizobactin 1021, thiamin, vibriobactin, yersiniabactin 4576 9462
Cluster 973 XCC3067(21232497), PA1271(15596468), RS02718(17547119), VC0156(15640186), BtuB(416728), CC1750(109897435), BPSL0976(53718618), Saro0693(23107401), CirA(2507462,16130093), FepA(16128567), PirA(2981053), PfeA(548479), FepA(2507463), IroN(2738252), CfrA(112360090),IrgA(12644182), BfrA(1314835), BfeA(538279), RSP_2402(77462960) Vitamin B12, catecholates,enterobactin, 2,3-dihydroxybenzoylserine(DHBS), 1677 1082
Cluster 325 SO_0815(24372404) Vitamin B12 168 91
Cluster 180 BF1991(53713281), BF0615(53711906), PG1899(34541505) Fibronectin, thiamin 113 1690
Cluster 2835 GOX1347(58039791) Thiamin 100 6
Group III: Heme/Hemophores/Iron(heme)-binding transporters Cluster 1609 HumA(53829495) Heme 413 1432
Cluster 1856 HxuC(1170441), PfhR(4838477), HgbA(28194090), HemR(3646475,6016198), HgbA(33152990), HpuB(11386826), HasR(34787214), HmbR(687640), HmuR(2501236), ChuA(1763009), ShuA(1655877), VctA(18476494), ShuA(82778670), TbpA(150361), FrpB4(15646121), HuvA(12697532), TdhA(33151615), BLL7076(27382187), LbpA(915278), HutA(529727, 148292078), HutR(147671724) Heme 1244 515
Group IV: Metal transporters Cluster 767 NosA(151399), OprC(1498191,15598985), Copper, Copper chelate 184 110
Cluster 987 Bll6948(27382059), Daro_3944(71909555), RPA_4757(39937815),pHCG3_081(47177035), Daro_1684(71907314) Nickel, Cobalt 64 0
Total number of sequences clustered together with the identified substrate dependent TBDTs 14206 26253
Total number of TBDTs 15905 44073
*

Standard gene or protein identificators of experimentally characterized TBDT and of TBDT with predicted substrate retrieved from GenBank based on References [26] and [27]. Designated numbers are given in brackets.

A list of the corresponding substrates for TBDT.