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. 2012 Jul 19;7(7):e41144. doi: 10.1371/journal.pone.0041144

Figure 1. Micellar GLA is a potent adjuvant for HIV gp140.

Figure 1

C57Bl/6 mice were immunized with 10 µg HIV gp140 antigen alone or in the presence of different formulations of GLA by the intramuscular (i.m.) or intranasal (i.n.) routes. Micellar GLA (GLA-AF) was given i.m. (Δ) or i.n. (▴) and emulsion GLA (GLA-SE: •) was given i.m., responses were compared to gp140 alone i.n. (▪). Anti-gp140 IgG was measured in sera of mice after prime (A) or boost (B) immunization. HIV gp140 specific IgG subtypes (C) and bone marrow long-lived plasma cells (D) were measured after 2 immunizations. Bars represent mean of n = 6 mice ± SEM, *p<0.05, **p<0.01, ***p<0.001.