Skip to main content
. 2012 Jul 19;7(7):e41144. doi: 10.1371/journal.pone.0041144

Figure 2. GLA is a more potent mucosal adjuvant than R848 or chitosan.

Figure 2

BALB/c mice were immunized i.n. three times at 3 week intervals with 10 µg gp140 and 10 µg GLA (▴), 10 µg R848 (○) or 100 µg chitosan (□) compared to antigen alone (▪). Serum (A, B), vaginal lavage (C, D), feces (E,F) were collected after each immunization and nasal lavage collected at d 63 only (G, H). gp140 specific IgG (A, C, E, G) and IgA (B, D, F, H) were measured by ELISA. Points represent mean of n = 10 mice ± SEM, *p<0.05, **p<0.01, ***p<0.001 comparing GLA and chitosan; #p<0.05, ##p<0.01, ###p<0.001 comparing GLA and R848.