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. 2012 Jul 19;7(7):e41374. doi: 10.1371/journal.pone.0041374

Figure 3. Nucleosome positioning near the CTCF-binding sites in K562 cells.

Figure 3

Nucleosome (blue lines) and CTCF-binding sites (red lines) profiles around cell type-specific (A), common (B), and ubiquitous (C) CTCF-binding sites are illustrated. Distances from the CTCF-binding sites are plotted along the x-axis. Left and right y-axes represent the normalized tag densities of the nucleosome and CTCF-binding sites, respectively. In (C), cyan ovals depict hypothetical nucleosome positions across the site with color intensities reflecting their positioning strength. The CTCF-binding site is indicated by the yellow rectangle. Left inset, linear fit to the positions of the phase peaks within 3 kb downstream of the CTCF-binding sites (slope  = 185.2 bp; 95% confidence interval (CI)  =  [184.6 bp, 185.7 bp]). Right inset, linear fit to the positions of the phase peaks within 3 kb upstream of CTCF-binding sites (slope  = 185.3 bp; 95% CI  =  [184.2 bp, 186.5 bp]).