Table 2. Cardiac function assessment.
| Sham (n = 12) | STNx + Vehicle (n = 17) | STNx + AST-120 (n = 13) | |
| HW/BW (g/kg) | 2.6±0.1 | 3.9±0.2*** | 3.7±0.2*** |
| LV/BW (g/kg) | 1.8±0.1 | 3.0±0.1*** | 2.8±0.1*** |
| Lung weight/BW (g/kg) | 3.1±0.1 | 3.6±0.1** | 3.4±0.1** |
| Echocardiography | |||
| LV mass (g/m2) | 1.55±0.03 | 1.98±0.06*** | 2.00±0.08*** |
| LVPWd (mm) | 1.63±0.03 | 2.09±0.12** | 2.06±0.11** |
| IVSd (mm) | 1.66±0.05 | 2.03±0.09** | 2.05±0.12** |
| E/A ratio | 1.91±0.15 | 1.43±0.09* | 1.55±0.15** |
| A velocity (m/s) | 0.52±0.03 | 0.74±0.05** | 0.74±0.06** |
| E’/A’ ratio | 1.62±0.20 | 1.11±0.11* | 1.13±0.12* |
| A’ velocity (cm/s) | 2.60±0.20 | 3.46±0.24* | 4.44±0.667* |
| E/E’ ratio | 0.25±0.01 | 0.30±0.02p = 0.08 | 0.29±0.03 |
| Millar catheterization | |||
| τ Logistic (msec) | 9.43±0.61 | 13.55±1.03* | 12.84±0.67 |
| τ Weiss-in steady state (msec) | 12.07±0.53 | 15.22±0.81* | 14.28±0.78 |
| LVESP (mmHg) | 86.95±3.87 | 86.37±6.04 | 92.82±9.34 |
| dP/dtmax (mmHg/s) | 5258±539 | 4837±350 | 4989±385 |
| PRSW (mmHg) | 76.12±7.10 | 69.92±3.88 | 76.60±5.03 |
| LVEDP (mmHg) | 5.26±0.49 | 6.42±0.47 | 6.21±0.40 |
| dP/dtmin (mmHg/s) | −4813±428 | −3940±337 | −4483±480 |
Data are presented as means ± SEM.
*
p<0.05.
***
p<0.001 vs Sham.
†
p<0.05.
†††
p<0.001 vs STNx + Vehicle.
HW/BW - heart weight/body weight; LV/BW - left ventricular weight/body weight; LV mass - left ventricular mass; IVSd - interventricular septal thickness in diastole; LVPWd - LV posterior wall thickness in diastole; dP/dtmax - rate of LV pressure rise; dP/dtmin - rate of LV pressure fall; LVEDP - LV end diastolic pressure; LVESP - LV end systolic pressure; PRSW - preload recruitable stroke work; τ (Tau) - load independent measure of isovolumetric relaxation time.