Table 3. Haplotypes of the BMP9 SNPs in cases and controls.
Haplotypes | rs7923671T>C | rs75024165C>T | rs34379100A>C | rs9421799C>A | Frequency | χ2(df = 1) | P(χ2) | P(MonteCarlo) | OR | 95%CI | |
OPLL | Control | ||||||||||
Haplotype 1 | C | T | C | A | 0.37 | 0.19 | 70.22 | <0.001 | <0.01 | 2.37 | 1.93–2.90 |
Haplotype 2 | T | C | A | C | 0.43 | 0.44 | 1.73 | 0.1882 | 1.00 | 0.89 | 0.74–1.06 |
Haplotype 3 | T | C | A | A | 0.07 | 0.11 | 12.13 | 0.0005 | 1.00 | 0.58 | 0.42–0.79 |
Haplotype 4 | T | T | A | A | 0.04 | 0.04 | <0.001 | 0.9988 | 1.00 | 1.00 | 0.64–1.56 |
Other haplotypes | – | 0.09 | 0.22 | – |
Note: Haplotype 1 includes the risk alleles of rs75024165 *T and rs34379100 *C (P<0.01).
p-value of haplotype by χ2 and Monte Carlo (Number of permutation = 100).