Table 1. Relative expression of known drug-resistance genes in doxorubicin resistant (DoxR) and vorinostat-treated doxorubicin-resistant (DoxR-v) cells compared to the parental lines.
| DoxR | DoxR-v | ||||
| Gene Symbol | Gene Entrez | SK-N-SH | SK-N-Be(2)C | SK-N-SH | SK-N-Be(2)C |
| ABCB1 (mdr1) | 5243 | 4.63 | 4.23 | 1.98 | 2.04 |
| ABCB6 (prp) | 10058 | 1.68 | 1.81 | 1.57 | 1.81 |
| ABCC3 (mrp3) | 8714 | N.D. | −2.39 | N.D. | N.D. |
| ABCC4 (mrp4) | 10257 | 2.17 | 2.12 | N.D. | N.D. |
| ABCC5 (mrp5) | 10057 | −1.63 | N.D. | −2.26 | −2.68 |
| ABCC9 (mrp9) | 10060 | −2.76 | −4.15 | −2.22 | −2.89 |
| BCL-2 | 596 | 1.53 | N.D. | N.D. | N.D. |
| SIRT1 | 23411 | 1.75 | 2.02 | N.D. | N.D. |
| BDNF | 627 | 3.69 | 5.17 | 2.56 | 3.60 |
| TH | 7054 | −1.87 | −2.47 | 25.5 | 31.0 |
Results are expressed as a fold-change (all p<0.1). N.D. indicates no difference in gene expression (fold-change<1.5 and/or p>0.1). The following genes had no significant difference in any comparison: ABCC1 (MRP1), ABCC2 (MPR2), ABCC6 (mrp6), ABCC8 (mrp8), ABCC10 (mrp10), ABCC11 (mrp11), ABCC12 (mrp12), ABCC13 (mrp13), MGMT, SOD, HDAC1-8.