Skip to main content
. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Figure 1. Flow-limited two-subcompartment and well-stirred PBPK tissue compartment model diagrams.

Figure 1

A) Flow-limited two-subcompartment (FLT) model, Eq.17; and B) well-stirred tank (WST) model, Eq.5. The flow-limited two-subcompartment model has both vascular (V1) and extravascular (V2) spaces and simulates total concentration in the compartment, cT, as a function of the volume and concentrations in each subcompartment. The outflow concentration differs between the flow-limited two-subcompartment and well-stirred tank models depending on the type of partition coefficient used (λbiophys or λwell-stirred) and the fractional blood volume (FBV) of the compartment. The flow-limited two-subcompartment model is a general flow-limited case of the PLT model. The well-stirred tank model is a specific flow-limited case of the PLT model where FBV → 0.