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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Figure 2. Flow-limited model simulations using a biophysical partition coefficient in a model representing the human kidney: a worst-case scenario.

Figure 2

A,B) Well-stirred tank with λbiophys (solid black lines, indicated by black arrowheads), well-stirred tank with λwell-stirred (solid light gray lines); flow-limited two-subcompartment with λbiophys (dashed black lines). Simulations are based on Eq.19 with ka = 0.001 sec−1 and kel = 0.0005 sec−1; physiological parameters: VT = 293 ml, FBV = 0.5, Q = 1138 ml · min−1; drug-specific parameter: A) λbiophys = 0.25 with λwell-stirred calculated based on Eq.18; B) λbiophys = 25 with λwell-stirred calculated based on Eq.18. Arbitrary units (a.u.) of concentration are plotted versus time in hours. Insets show overlapping peak concentration-time curves for the well-stirred tank model with λwell-stirred and the flow-limited two-subcompartment model with λbiophys.