Figure 4. Simulated concentration-time curves using a priori predicted partition coefficients for diazepam.

Plasma, adipose, brain, heart, kidney, liver, lung, muscle, skin, splanchnic, stomach, and testes concentration-time curves are simulated using a priori predicted partition coefficients based on the method of Poulin et al. [4] with the correction by Berezhkovskiy [24]. Well-stirred tank (solid black lines) and flow-limited two-subcompartment (dashed gray lines) model simulations are plotted against pharmacokinetic data (open circles) in the rat from Gueorguieva et al. [20]. Diazepam partition coefficient values are reported in Table 2, and AUC values are reported in Table 3.