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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Figure 5. Simulated concentration-time curves using well-stirred and flow-limited two-subcompartment model-optimized partition coefficients for diazepam.

Figure 5

Lower fractional blood volume tissues (adipose, brain, muscle, skin, splanchnic, stomach, and testes), higher fractional blood volume tissues (heart, kidney, liver, lung), and plasma concentration-time curves are simulated using optimized partition coefficients. The well-stirred model is used to optimize diazepam well-stirred partition coefficients, and the flow-limited two-subcompartment model is used to optimize diazepam biophysical partition coefficients (Table 2). Well-stirred tank (solid black lines) and flow-limited two-subcompartment (dashed gray lines) model simulations are plotted against pharmacokinetic data (open circles) in the rat from Gueorguieva et al. [20]. AUC values are reported in Table 3.