Figure 6. Simulated concentration-time curves using a priori predicted partition coefficients for cotinine.

Adipose, brain, heart, kidney, liver, lung, muscle, and splanchnic concentration-time curves are simulated using a priori predicted partition coefficients based on the method of Poulin et al. [4] with the correction by Berezhkovskiy [24]. Well-stirred tank (solid medium gray lines) and flow-limited two-subcompartment (dashed dark gray lines) model simulations are plotted against rat pharmacokinetic data from Gabrielsson, et al. [27] (filled dark gray circles, mean; vertical bars, range). Plasma concentration-time curves are also plotted in each tissue panel (well-stirred, solid light gray lines; flow-limited two-subcompartment, dashed medium gray lines) against rat plasma time course data (filled light gray squares, mean; vertical bars, range). Partition coefficient values for cotinine are reported in Table 4, and AUC values are reported in Table 5.