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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Figure 8. Relationship between the biophysical and well-stirred partition coefficients at a set fractional blood volume.

Figure 8

A,B) The fractional blood volume is arbitrarily set to 0.36 (rat lung). The shaded gray areas indicate the biophysical partition coefficient is <1. A) The ratio of λwell-stirred to λbiophys versus λbiophys. The ratio is always >1 when λbiophys is <1. When λbiophys is >1, the upper and lower dashed lines are the bounds on the ratio of λwell-stirred to λbiophys for a given fraction blood volume (FBV). B) The percent difference between λbiophys and λwell-stirred versus λbiophys. The percent difference is always negative when λbiophys is <1. When λbiophys is >1, the upper and lower dashed lines are the bounds on the percent difference for a given fraction blood volume (FBV).