. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Table 1.

Physiological parameter values for a 250 g rat

Tissue	Rat^a		Fractional Blood Volume^b (FBV)
	Flow	Weight	Fractional Blood Volume^b (FBV)

	ml/min	g	mean	range
Adipose	2.55	10	0.02(h)	0.02–0.03(h)
Brain	0.78	1.2	0.03(r), 0.04(h)	0.02–0.04(r), 0.03–0.1(h)
Heart	4.2	1	0.26(r)	-
Kidney	16.61	2	0.16(r), 0.36(h)	0.11–0.27(r), 0.22–0.5(h)
Liver	3.55	11	0.21(r), 0.11(h)	0.12–0.27(r)
Lung	80	1.2	0.36(r)	0.26–0.52(r)
Muscle	16.25	125	0.04(r), 0.01(h)	0.01–0.09(r)
Skin	7.1	43.8	0.02(r), 0.08(h)	-
Splanchnic	20.25	15	0.035(r)^c	-
Stomach	1.9	1.1	0.035(r) ^c	-
Testes	1.9	2.5	0.017(r) ^c	-
Remainder	4.91	15.8	0.05^d	-
Venous	80	13.6	-	-
Arterial	80	6.8	-	-
Whole Body	80	250	-	-

Gueorguiev a, et al. [20]

Brown, et al. [17], r-rat, h-human

estimated from Everett, et al. [25], r-rat

assumed