Table 2.

Partition coefficients and clearance for diazepam case study

Tissue	FBVa	Partition Coefficients for Diazepamb
		λapriori	λbiophys	λwell-stirred
Adipose	0.02	15.2	23.1	23.1
Brain	0.03	7.1	2.2	2.2
Heart	0.26	2.5	5.4	4.3
Kidney	0.16	2.9	5.7	5.2
Liver	0.21	3.1	9.7	9.1
Lung	0.36	3.5	7.3	5.3
Muscle	0.04	1.9	2.5	2.4
Remainderc	0.05	4.9	16.0	16.5
Skin	0.02	3.9	3.1	3.2
Splanchnic	0.035	4.4	4.1	4.3
Stomach	0.035	4.9	4.5	4.5
Testes	0.017	4.9	4.6	4.7
		CLINT (ml/min)
Clearance		83d	374e	422e

^aMean rat fractional blood volumes (FBV) from Table I

^bλ_apriori is the a priori predicted tissue:plasma partition coefficients for diazepam estimated using the method of Poulin et al. [4] with the correction by Berezhkovskiy [24]; λ_biophys is the biophysical partition coefficient between the two subcompartments; λ_well-stirred is the well-stirred partition coefficient of the single compartment well-stirred tank; the partition coefficients, λ_biophys and λ_well-stirred, are determined via optimization

^cStomach and testes compartments are given the same λ_apriori partition coefficient values as the remainder (λ_apriori = 4.9)

^dPredicted intrinsic clearance from Poulin, et al. [5]

^eOptimized intrinsic clearance value corresponding to each given set of optimized partition coefficients