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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Table 3.

Area under the curve (AUC) for diazepam simulations with the flow-limited two-subcompartment and well-stirred tank models

Tissue AUC for Diazepama
FLT (λapriori)b (×1010) WST (λapriori)c (×1010) %diffd FLT-opt (λbiophys)e (×1010) WST-opt (λwell-stirred)f (×1010) %diffg
Adipose 14.0 14.3 −1.9 9.90 9.70 2.1
Brain 4.93 5.09 −3.4 0.50 0.48 3.2
Heart 1.35 1.61 −19.3 0.94 0.92 2.5
Kidney 1.66 1.86 −12.5 1.10 1.08 1.5
Liver 1.19 1.40 −17.6 0.58 0.59 −1.9
Lung 1.67 2.26 −35.7 1.09 1.09 0.2
Muscle 1.39 1.42 −2.6 0.71 0.68 3.7
Remainder 3.55 3.73 −5.1 6.02 6.37 −5.9
Skin 3.05 3.11 −2.0 0.92 0.91 0.6
Splanchnic 2.83 2.93 −3.5 0.91 0.95 −4.0
Stomach 3.16 3.27 −3.6 1.00 0.98 2.6
Testes 3.34 3.41 −2.0 1.10 1.08 1.5
Plasma (art)h 0.64 0.64 −0.7 0.22 0.21 5.0
Plasma (ven)h 0.64 0.64 −0.6 0.22 0.21 5.0
a

Area under the curve (AUC) for time courses plotted in Figs. 4 and 5.

b

AUC values based on using diazepam λapriori values in the flow-limited two-subcompartment (FLT) model

c

AUC values based on using diazepam λapriori values in the well-stirred tank model (WST)

d

Percent difference in AUC between FLT and WST models using λapriori calculated as [(AUCFLT − AUCWST)/AUCFLT]×100

e

AUC values based on using diazepam λbiophys optimized with the flow-limited two-subcompartment model

f

AUC values based on using diazepam λwell-stirred optimized with the well-stirred tank model

g

Percent difference in AUC between FLT and WST models using optimized partition coefficients calculated as [(AUCFLT − AUCWST)/AUCFLT]×100

h

Arterial compartment (art) and venous compartment (ven)