Table 4.

Partition coefficients and clearance for cotinine case study

Tissue	FBVa	Partition Coefficients for Cotinineb
		λapriori	λbiophysc	λwell-stirredd
Adipose	0.02	0.61	0.02	0.04
Brain	0.03	0.87	0.25	0.27
Heart	0.26	0.82	0.03	0.28
Kidney	0.16	0.82	0.67	0.72
Liver	0.21	0.76	0.23	0.39
Lung	0.36	0.83	0.001*	0.30
Muscle	0.04	0.79	0.26	0.29
Remaindere	0.05	0.78	0.14	0.18
Splanchnic	0.035	0.79	0.28	0.31
		CLINT (ml/min)
Clearance		0.21	0.13f	0.13g

^aMean rat fractional blood volumes (FBV) from Table I

^bλ_apriori is the a priori predicted tissue:plasma partition coefficients for cotinine estimated using the method of Poulin et al. [4] with the correction by Berezhkovskiy [24]; λ_biophys is the biophysical partition coefficient between the two subcompartments; λ_well-stirred is the well-stirred partition coefficient of the single compartment well-stirred tank.

^cThe λ_biophys partition coefficients are calculated from optimized λ_well-stirred values using Eq.18 with the partition coefficient for lung being set arbitrarily low (indicated by *)

^dThe λ_well-stirred partition coefficients are determined via optimization

^eSkin, stomach, and testes were kept as compartments in the model but were given the same respective partition coefficient value as the remainder (λ_apriori = 0.78, λ_biophys = 0.14, or λ_well-stirred = 0.18)

^fWell-stirred tank-optimized intrinsic clearance value is used in flow-limited two-subcompartment simulations

^gWell-stirred tank-optimized intrinsic clearance value