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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 May 26;39(4):313–327. doi: 10.1007/s10928-012-9252-6

Table 5.

Area under the curve (AUC) for cotinine simulations with the flow-limited two-subcompartment and well-stirred tank models

Tissue AUC for Cotininea
FLT (λapriori)b (×1011) WST (λapriori)c (×1011) %diffd FLT-calc (λbiophys)e (×1011) WST-opt (λwell-stirred)f (×1011) %diffg
Adipose 3.31 3.25 1.7 0.23 0.23 −0.1
Brain 4.68 4.63 0.9 1.77 1.77 −0.1
Heart 4.63 4.36 5.8 1.85 1.86 −0.1
Kidney 4.53 4.36 3.8 4.76 4.76 −0.1
Liver 4.29 4.01 6.7 2.56 2.57 −0.1
Lung 4.76 4.41 7.3 2.37 2.00 15.7
Muscle 4.29 4.23 1.5 1.89 1.89 −0.1
Remainder 4.24 4.16 1.8 1.21 1.21 −0.1
Splanchnic 4.26 4.20 1.4 2.03 2.04 −0.1
Plasma (art)h 5.34 5.32 0.5 6.58 6.59 −0.1
Plasma (ven)h 5.34 5.32 0.5 6.58 6.59 −0.1
a

Area under the curve (AUC) for time courses plotted in Figs. 6 and 7.

b

AUC values based on using cotinine λapriori values in the flow-limited two-subcompartment model (FLT)

c

AUC values based on using cotinine λapriori values in the well-stirred tank model (WST)

d

Percent difference in AUC between FLT and WST models using λapriori calculated as [(AUCFLT − AUCWST)/AUCFLT]×100

e

AUC values based on using calculated cotinine λbiophys (calculated from optimized λwell-stirred values using Eq.18)

f

AUC values based on using optimized cotinine λwell-stirred (optimized with the well-stirred tank model)

g

Percent difference in AUC between FLT and WST models calculated as [(AUCFLT − AUCWST)/AUCFLT]×100

h

Arterial compartment (art) and venous compartment (ven)