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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Circ Cardiovasc Imaging. 2012 May 7;5(4):481–490. doi: 10.1161/CIRCIMAGING.111.969329

Figure 1.

Figure 1

Human cardiac progenitor cell (hCPC) phenotype is unaffected by expression of thymidine kinase PET reporter genes. (A) Schematic of lentiviral constructs expressing four variant thymidine kinase PET reporter genes. (B) No significant difference in proliferation rate was observed among hCPCs transduced with various thymidine kinase reporter genes versus control untransduced hCPCs. (C) Immunohistochemical staining of differentiating hCPCs demonstrates cells of all three cardiac lineages: myocyte (marked by α-actinin), endothelial (marked by CD31), and smooth muscle (marked by α-SMA) after transduction with thymidine kinase reporter genes. Fibroblasts (far right) serve as a negative control and do not stain for any cardiac markers.