Table 3. Clients' perceived opinions and experiences with DTC-GT.
| Client, n=25 | |
|---|---|
| n (%) | |
| Type of DTC-GT ordered | |
| Testing of multiple SNPs or CNVs in multiple genes | 10 (40) |
| Whole exome sequencing (next generation sequencing) | 4 (16) |
| Whole genome sequencing (next generation sequencing) | 4 (16) |
| Full sequencing of two or more genes | 3 (12) |
| Full sequencing of a single gene | 2 (8) |
| Testing of one or more SNPs or CNVs in a single gene | 1 (4) |
| Unknown | 1 (4) |
| Motivation for having DTC-GT (≥1 motivation per client) | |
| To know their susceptibility/predisposition for complex conditions | 14 (56) |
| To identify monogenic conditions, including carrier testing | 9 (36) |
| For academic purposes (eg, interest or curiosity) | 3 (12) |
| For other non health-related applications (eg, ancestry, nutrigenetics, paternity testing) | 1 (4) |
| For pharmacogenetic uses | 0 (0) |
| To assess their sporting ability | 0 (0) |
| Reasons given for seeking professional services in regard to their DTC-GT (≥1 reason per client) | |
| Needed help interpreting the results | 20 (80) |
| Concerned for health of family members | 15 (60) |
| Seeking reproductive risk information | 11 (44) |
| Concerned for own health | 10 (40) |
| Seeking information on specific conditions | 10 (40) |
| Seeking further genetic testing | 4 (16) |
| Questioning validity of DTC-GT results | 2 (8) |
| Satisfaction with chosen DTC-GT service | |
| Very satisfied | 8 (32) |
| Somewhat satisfied | 8 (32) |
| Not satisfied | 9 (36) |
| Feelings of regret for having DTC-GT | |
| No | 14 (56) |
| Yes | 5 (20) |
| Unknown | 6 (24) |
Abbreviations: CNV, copy number variation; DTC-GT, direct-to-consumer genetic testing; SNP, single-nucleotide polymorphism.