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(a) Scatter plot of 86 10-kb dsDNA events at 600 mV in 100 mM KCl. Seventeen of the 86 events show a decrease in the ionic current before translocation (top trace). The remaining events exhibit only the typical translocation induced increase in the ionic current (bottom trace). (b) 285 10-kb dsDNA translocation events through the same nanopore as in panel a, at 500 mV in 1 M KCl. Current traces show representative events from different areas of the scatter plot.
