TABLE 2.
Summary of the mean (S.D.) pharmacokinetic parameters of oseltamivir and oseltamivir carboxylate after a single oral dose of oseltamivir (30 mg/kg) to adult fed rats (n = 3/group)
Oseltamivir was dosed either as a water solution, as a solution in milk, or as 125 mM aqueous Gly-Sar. Statistical analysis was performed on Cmax, tmax, AUC0–6h, and AUC0-∞ values; bovine milk (group 2) and Gly-Sar (group 3) treatments were compared with water (group 1). No statistically significant difference was observed.
| Pharmacokinetic Parameter | Oseltamivir |
Oseltamivir Carboxylate |
||||
|---|---|---|---|---|---|---|
| Water Group 1 | Bovine Milk Group 2 | Gly-Sar Group 3 | Water Group 1 | Bovine Milk Group 2 | Gly-Sar Group 3 | |
| Cmax, μg/l | 1270 (325) | 1430 (250) | 926 (180) | 1110 (136) | 1310 (374) | 693 (104) |
| tmax, h | 0.41 (0.14) | 0.41 (0.14) | 0.66 (0.14) | 0.75 (0) | 0.75 (0) | 1.42 (0.63) |
| AUC0–6h, μg/l · h | 2200 (185) | 2510 (606) | 2280 (383) | 3540 (562) | 4510 (1440) | 2960 (469) |
| AUC0–24h, μg/l · h | 2510 (172) | 2800 (597) | 2830 (507) | 5280 (861) | 6330 (1680) | 4860 (998) |
| AUC0-∞, μg/l · h | 2510 (175) | 2810 (589) | 2840 (506) | 5290 (862) | 6340 (1670) | 4870 (999) |