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Dose-dependent reinstatement by the β-adrenergic receptor agonist isoproterenol in wild-type C57BL/6J mice. Data represent time spent in the cocaine-paired side (s ± S.E.) during reinstatement testing after pretreatment with isoproterenol (0, 1, 2, or 4 mg/kg i.p.) or during the preceding extinction session (Ext). Isoproterenol induced reinstatement at the 2 and 4 mg/kg doses. *, p < 0.05 versus extinction.
