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. 2012 Aug;342(2):407–415. doi: 10.1124/jpet.111.191296

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Fig. 5. — Effect of diabetes on circulating and tissue (MCA) nitrotyrosine levels. A, basal nitrotyrosine (NY) levels are higher in plasma samples from chronically diabetic rats. **, p < 0.01 vs. control. B, a 2 (control vs. diabetes) × 2 (untreated vs. OGD) analysis of data indicated that there is a disease and treatment interaction in response to OGD treatment in control vs. diabetic vessels. OGD increases whole MCA nitrotyrosine levels in control but not in diabetes. **, p < 0.01 vs. untreated. Treatment with FeTPPs (2.5 μM) counteracts this response in controls without any effect on diabetic vessels. *, p < 0.05 vs. OGD. IOD, integrated optical density. Results are given as mean ± S.E.; n = 3–8.