Fig. 1.

Properties of electrically evoked EJPs recorded from mouse detrusor muscle. A, the effect of 2 μM TTX on electrically evoked responses recorded from detrusor muscle. sEJPs (indicated by *) were still present after abolition of the evoked response by TTX. B, the effect of the inorganic voltage-dependent Ca²⁺ channel blocker Cd²⁺ (200 μM) on electrically evoked responses. Cd²⁺ produced a rapid abolition of the evoked response, indicating the calcium dependence of the evoked EJP. C, the effect of the P2X₁ receptor antagonist NF279 (15 μM) on electrically evoked responses. Application of NF279 abolishes the evoked response, indicating the purinergic nature of these responses.