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Suggested mechanism of motilin-induced gastric migrating motor complex by Dr. Itoh.25 Released motilin from the duodenal mucosa reaches at the area postrema and activates 5-hydroxytryptamine (5-HT) neurons at the dorsal vagal complex. Stimulation of 5-HT neurons activates vagal efferents through 5-HT3 receptors. DVC, dorsal vagal complex; ACh, acetylcholine; MMC, migrating motor complex.
