TABLE 7.
PGI2 and TXA2 metabolite levels in representative pregnancy and neonatal disorders vs. levels in normal pregnant or newborn subjects or experimental animals
Most studies showed consistently increased TXB2, with decreased, increased, or unchanged 6-keto-PGF1α and a net decrease in PGI2/TXA2 ratio.
| Disorder | Subject/Animal | Sample | 6-keto-PGF1α | TXB2 | PGI2/TXA2 | Reference |
|---|---|---|---|---|---|---|
| Preeclampsia | Pregnant women | Blood (1st trimester) | 545 ± 4 vs. 551 ± 28.4 pg/ml | 188 ± 17 vs. 119 ± 4.8 pg/ml | 3.1 ± 0.18 vs. 4.6 ± 0.12 | Chavarria et al., 2003 |
| Blood (3rd trimester) | 191 ± 9.8 vs. 288 ± 10.4 pg/ml | 90 ± 4.6 vs. 72 ± 2 pg/ml | 2.05 ± 0.06 vs. 3.9 ± 0.07 | Chavarria et al., 2003 | ||
| Human placenta | Cytotrophoblast culture | 0.38 ± 0.05 vs. 0.20 ± 0.05 pg/μg | 4.33 ± 1.03 vs. 1.84 ± 0.29 pg/μg | ≈ 0.087 vs. ≈ 0.108 | Bowen et al., 2005 | |
| Maternal diabetes | Pregnant women with insulin-dependent diabetes | In vitro perfused placenta with labeled AA | 18 vs. 23% | 9.5 vs. 5% | 1.9 vs. 4.5% | Kuhn et al., 1990 |
| PPHN | Lamb, in utero induced PPHN (by partial DA constriction) | Lung tissue | ≈ 7700 vs. ≈ 4200 pg/g | ≈ 9000 vs. ≈ 1500 pg/g | ≈ 0.8 vs. ≈ 3 | Abman and Stenmark, 1992 |
| Piglet hypoxia-induced PPHN | Cannulated small pulmonary artery | 45 ± 6 vs. 103 ± 27 pg/mg | 2.3 ± 4.5 vs. 0.8 ± 0.2 pg/mg | ≈ 25 vs. ≈ 200 | Fike et al., 2003 | |
| ROP | Newborn piglet hypoxia-model of ROP | Retinal tissue | ≈ 40 vs. ≈ 20 pmol/g protein | ≈ 30 vs. ≈ 10 pmol/g protein | ≈ 1.3 vs. ≈ 2.1 | Chemtob et al., 1995 |
| 5 min after hypoxia | ||||||
| 60 min after hypoxia | ≈ 30 vs. ≈ 20 pmol/g protein | ≈ 50 vs. ≈ 10 pmol/g protein | ≈ 0.6 vs. ≈ 2.1 | Chemtob et al., 1995 | ||
| HIE | Human newborn with moderate to severe HIE | CSF | 168.47 vs. 86.23 ng/l | 206.06 vs. 41.77 ng/l | 0.82 vs. 2.06 | Liu et al., 2003 |