Fig. 6.

Structural analogs of chlorpropamide. Ester analog of chlorpropamide, (benzoyloxy)[(4-chlorophenyl)sulfonyl]carbamic acid 1,1-dimethylethyl ester (NPI-1). Alkyl analog of chlorpropamide, 4-chloro-N-ethyl-N-[(propylamino)carbonyl]benzenesulfonamide (API-1). [Reprinted from Rekha GK, Devaraj VR, Sreerama L, Lee MJ, Nagasawa HT, and Sladek NE (1998) Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues. Biochem Pharmacol 55:465–474. Copyright © 1998 Elsevier. Used with permission.]