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. 2012 Aug;82(2):344–359. doi: 10.1124/mol.112.078568

Fig. 11.

Fig. 11.

The RMSF reported for molecular dynamics simulations performed for mutant ATD heterodimers. A, the RMSF is illustrated for the GluN1/GluN2B(Y282A) ATD simulated in the apo state. B, the RMSF is similarly shown for the GluN1/GluN2B(Y282A) ATD simulated with ifenprodil bound. A thicker ribbon with warmer colors (yellow and red) represents regions with enhanced Cα fluctuations compared with average of all residues. The two boxes highlight regions of interest for which there were increased fluctuation in wild-type ATD. The boxes represent GluN1 residues 126 to 135 and GluN2B residues 261 to 275. C, the average RMSF over all GluN1 ATD Cα carbons was 1.6 to 2.7 Å and 1.6 to 2.1 for all GluN2B ATD residues across all simulations with mutant ATD. The table summarizes the average and range of RMSF for residues within the two highlighted regions in (A) and (B).