TABLE 1.

The structures of ligands docked to the hydrated model of GluN1/GluN2B

GluN2B-selective negative allosteric modulators that were used in docking studies to better understand the mechanism of action and their interactions within the GluN1/GluN2B interface are shown. The compounds are aligned with the general pharmacophore model (top) to illustrate how they interact with the binding interface. Published IC₅₀ values were obtained from the references in the footnotes; for compound 93-138, the IC₅₀ (0.384 μM) was determined from 20 oocytes as described under Materials and Methods.

Compound	Structure	IC50	Compound	Structure	IC50
		μM			μM
Ifenprodila		0.040	Compound 68b		0.065
Ro-25-6981c		0.009	Compound 49b		0.051
Ro-63-1908d		0.003	Compound 15b		0.028
Traxoprodile		0.0039	Bensonprodilf		0.008
Eliprodilg		1.0	Compound 3ah		0.002
Compound 37ai		0.0097	Compound 3dh		0.003
Compound 29j		0.051	Compound 46bk		0.005
Compound 52b		0.054	Radiprodill		0.003
Compound 93–138		0.501	Compound 12am		0.018

^a Chenard et al., 1991.

^b Mosley et al., 2009.

^c Fischer et al., 1997.

^d Gill et al., 2002.

^e Mott et al., 1998.

^f Nagy et al., 2003.

^g Avenet et al., 1996.

^h Barta-Szalai et al., 2004.

ⁱ McCauley et al., 2004.

^j Tahirovic et al., 2008.

^k Wright et al., 2000.

^l Mony et al., 2009.

^m Butler et al., 1998.