Skip to main content
. 2012 Jul 21;18(27):3502–3510. doi: 10.3748/wjg.v18.i27.3502

Figure 1.

Figure 1

Schematic representation of the regenerating islet-derived type IV signaling pathway. Regenerating islet-derived type IV (RegIV) contributes to cell proliferation, inhibition of apoptosis, and carcinogenesis via protein kinase B (Akt) signaling pathway by transactivating the epidermal growth factor receptor (EGFR). The primary signaling pathway is now being investigated. MBS: Mannan-binding sites; PI3K: Phosphoinositide 3-kinase; PIP2: Phosphatidylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol 4,5-triphosphate; PDK1: Phosphoinositide-dependent kinase-1; Bcl-2: B-cell lymphoma 2.