Table 4.

Articles reporting regenerating islet-derived type IV-targetted therapy

Author	Year	Method/type of cancer	Result
Bishunpuri et al[53]	2006	Transfection of rhR4/colorectal	Increase in pEGFR and pAkt
Takehara et al[20]	2006	Transfection of rhR4 and siRNA/pancreatic	Significant reduction in viable cells andincrease in pAkt
Legoffic et al[72]	2009	RegIV antibody injection/pancreatic	Significant reductions in Akt, Bcl-2 and Bcl-xL

rhR4: Recombinant human regenerating islet-derived type IV; RegIV: Human regenerating islet-derived type IV; siRNA: Small interfering RNA; pEGFR: Phosphorylated epidermal growth factor receptor; pAkt: Phosphorylated protein kinase B; Akt: Protein kinase B; Bcl-2: B-cell lymphoma 2; Bcl-xL: B-cell lymphoma-extra large.