Table I.

Values of the mean heart rate [beats/min] in rats fed normo- and hypercholesterolemic diet measured after 4-wk administration of drugs

K	429.81±19.50
K_H	418.03 ±29.05
S	430.66 ±27.76
S_H	420.51 ±9.18
IW	350.18 ±16.02*
IW_H	363.05 ±21.68*
M	390.76 ±20.54*
M_H	384.28 ±21.87*
SIW	312.02 ±30.25*,a,b
SIWH	329.83 ±24.16*,a,b
SM	370.54 ±15.55*,a
SM_H	386.50 ±22.20*,a

K – normocholesterolemic control group, K_H – hypercholesterolemic control group, IW – normocholesterolemic group receiving ivabradine, IW_H – hypercholesterolemic group receiving ivabradine, S – normocholesterolemic group receiving simvastatin, S_H – hypercholesterolemic group receiving simvastatin, SIW – normocholesterolemic group receiving simvastatin with ivabradine, SIW_H – hypercholesterolemic group receiving simvastatin with ivabradine

^*p < 0.05 as compared to control group

^ap < 0.05 as compared to rats receiving simvastatin alone

^bp < 0.05 as compared to rats receiving ivabradine alone