Table 2.
Relationship of in Vitro Phenotypea of SIV and SHIV to Vaginal Transmission in Rhesus Macaques
| Virus isolate/clone | Plasma antigenemia after intravenous inoculation | PBMC load after intravenous inoculation | Vaginal transmission |
|---|---|---|---|
| SIVmac251 | + | High | Yes |
| SIVmac239 | + | High | Yes |
| SIVmaclAll/239 | + | Intermediate | Yes |
| SHIV89.6 | + | Intermediate | Yes |
| SHIV89.6PD | + | High | Yes |
| SIVmaclAll | – | Low | No |
| SHIVHXBc2 | – | Intermediate | No |
a
The data were generated by characterizing the virologic parameters in rhesus macaques that were infected with each virus clone or isolate by intravenous inoculation.