Table 2.
Polymerase chain reaction (PCR)-based detection of simian immunodeficiency virus (SIV) gag DNA sequences in peripheral blood mononuclear cells (PBMC) of targeted iliac lymph-node (TILN)-immunized and control rhesus macaques after intravaginal challenge with SIVmac251.
| Challenge timepoint (week) |
Week post-challenge | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Macaques | Vaccine | No. vaccinations |
1 | 2 | 4 | 8 | 12 | 16 | 20 | |
| Group A | ||||||||||
| 22575 | Whole SIV | 3 | 10 | + | + | + | + | + | + | + |
| 24331 | Whole SIV | 3 | 10 | + | + | + | + | + | + | |
| 25428 | Whole SIV | 3 | 10 | + | + | + | + | + | + | + |
| Group B | ||||||||||
| 21747 | p27 + gp120 | 3 | 10 | + | + | + | + | + | + | + |
| 24816 | p27 + gp120 | 3 | 10 | + | + | + | + | + | + | + |
| 24428 | p27 + gp120 | 3 | 10 | + | + | + | + | + | + | + |
| Group C | ||||||||||
| 25255 | None | 0 | 10 | + | + | + | + | + | + | + |
| 25422 | None | 0 | 10 | + | + | + | + | + | + | + |
| 24803 | None | 0 | 10 | + | +* | |||||
| 25597 | None | 0 | 10 | + | +* | |||||
| Group D | ||||||||||
| 20634 | Pr55 + gp130 | 4 | 17 | + | + | + | + | + | + | + |
| 22212 | Pr55 + gp130 | 4 | 17 | + | + | + | + | + | + | + |
| 22590 | Pr55 + gp130 | 4 | 17 | + | + | + | + | + | + | + |
| Group E | ||||||||||
| 26665 | None | 0 | 17 | − | − | − | + | + | − | − |
| 26742 | None | 0 | 17 | + | + | + | + | + | + | + |
Animals were killed at this time for experimental reasons unrelated to this study.