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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Bioconjug Chem. 2012 Mar 8;23(3):604–609. doi: 10.1021/bc200648m

Figure 1. Effectiveness of fractionated Pan-IR700 with multiple NIR light exposures as detected by IR700 fluoresence.

Figure 1

Pan-IR700 was administered to A431 tumor-bearing mice which were then exposed to NIR light and imaged with a fluorescent camera. (a) IR700 fluorescence of A431 tumors over time (n = 3 mice in each group). (b) Images of A431 tumor bearing mice before (left), immediately after (center) and 24 h after (right) PIT with 50 J cm-2 NIR light irradiation. IR700 fluorescence signal in the tumor decreased to background level immediately after PIT (center). Signal within the tumor increased 24 h after PIT indicating reaccumulation of Pan-IR700 due to circulating Pan-IR700 (right). (c) IR700 fluorescence of A431 tumor before and after NIR light irradiation. Data are mean ± s.e.m. (n = 4 mice). (d) Tumor volume reduction in response to Pan-IR700 PIT in A431 xenograft tumor (n≥3 10 mice in each treatment group).