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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Mar 12;51(19):4572–4576. doi: 10.1002/anie.201200387

Table 1.

Regio- and stereoselective transformations of lactam (–)-18.

graphic file with name nihms365044f6.jpg
a

Grignard reagents at −40 °C. Other nucleophiles at 23 °C.

b

Isolated yield of single diastereomer.

c

93% Deuterium incorporation at C19.

d

Isolated as C19 iminium triflate. 2-ClPyr = 2-chloropyridine.