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. 2012 Jul 20;7(7):e41094. doi: 10.1371/journal.pone.0041094

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(A) γH2AX, pS1981-ATM and actin protein expression detected by Western blotting in WT ant Top1mt−/− cells. (B) γH2AX visualization by immunofluorescence and relative quantification in WT and Top1mt−/− cells. (C) Cell cycle analysis of WT and Top1mt−/− cells. (D) Detection of γH2AX by Western blotting after ROS inhibition with 10 mM of NAC for 3 h in WT and Top1mt−/− cells. (F) Immunostaining of intestine sections with γH2AX antibody in control and Top1mt−/− mice livers.