Table 3. Genes of interest from previous studies.

Category	Gene name	Group of study(reference(s))	CoccidioidesGene ID	C. immitisexp. ratio*	C. posadasiiexp. ratio*
Dimorphism regulation	4-hydroxyl-phenyl pyruvate dioxygenase(4-HPPD)	Paracoccidioides [24], [25]	CIMG_01466	3.52**	4.90**
	DRK1	Multiple [21], [62]	CIMG_04512	0.87	0.59**
	Ornithine decarboxylase (ODC)	Coccidioides [23]	CIMG_08778	0.84	1.92**
	RYP1 (WOR1, TOS9)	Multiple [21], [22]	CIMG_02671	0.91	1.20**
	RYP2	Histoplasma [20]	CIMG_01530	0.61	0.63
	RYP3	Histoplasma [20]	CIMG_09962	0.38**	0.32**
Virulence Factors	Alpha (1,3) glucan synthase (AGS1)	Multiple [26], [27], [28], [29]	CIMG_13256	1.93**	1.59**
	1,3-beta-glucanosyltransferase	Coccidioides [25]	CIMG_00181	1.06	3.64**
	Metalloprotease 1 (MEP1)	Coccidioides [32]	CIMG_08674	0.34**	2.04**
	Urease	Coccidioides [37]	CIMG_04935	1.60	2.38**
	Urease accessory protein	Coccidioides	CIMG_05165	1.46**	0.76
	Ureidoglycolate hydrolase (UGH)	Coccidioides	CIMG_02178	1.89**	3.48**
Cellular processes	GAC1	Saccharomyces	CIMG_05377	6.62**	18.18**
	GLC7	Saccharomyces	CIMG_04906	0.63**	0.55**
	SEC1	Saccharomyces [33], [34]	CIMG_00724	1.94**	1.72**

^*Expression ratio: parasitic/saprobic expression. Ratios >1.0 indicate higher expression (up-regulation) in the parasitic phase and ratios <1.0 indicate higher expression (up-regulation) in the saprobic phase.

^**p-value <0.05.