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. Author manuscript; available in PMC: 2012 Jul 21.
Published in final edited form as: Nature. 2012 Mar 4;483(7389):355–358. doi: 10.1038/nature10865

Figure 1. Polyether natural products and proposed steps in the cyclic ether formation.

Figure 1

a, An example of a cascade epoxide ring closure implicated in the biosynthesis of ladder polyether. b, Structures of representative ionophore polyethers. c, Plausible mechanism of epoxide-mediated cyclic ether formation leading to the formation of lasalocid A, isolasalocid A and the product analogues.