Table 1.

Hematologic parameters of WT and BERK mice as well as WT^BM and BERK^BM mice treated with 1H1 rat anti–mouse TF or control rat IgG antibodies

Variable	WT	BERK	WTBM/IgG	WTBM/1H1	BERKBM/IgG	BERKBM/1H1
RBCs, 106/μL	8.3 ± 0.9	4.7 ± 0.6	7.2 ± 0.6*	7.0 ± 0.5	4.8 ± 0.3†††	5.2 ± 0.5‡‡‡
Hemoglobin, g/dL	9.1 ± 0.8	4.2 ± 0.8	7.1 ± 0.4***	7.2 ± 0.3	4.6 ± 0.3†††	4.7 ± 0.4‡‡‡
Hematocrit, %	36.9 ± 1.1	21.4 ± 2.6	30.2 ± 2.1***	30.7 ± 1.2	23.1 ± 1.6†††	24.1 ± 2.1‡‡‡
MCV, fL	45.4 ± 4.9	45.7 ± 4.3	42.2 ± 4.5	44.2 ± 3.4	47.9 ± 2.4†††	46.1 ± 2.4
MCH, pg	NA	NA	9.9 ± 0.3	10.5 ± 0.6	9.6 ± 0.9	9.3 ± 0.8‡
MCHC, g/dL	NA	NA	24.1 ± 2.4	24.0 ± 1.9	20.2 ± 1.5†††	20.1 ± 1.4‡‡
RDW, %	18.3 ± 3.9	31.5 ± 2.9	18.9 ± 3.2	18.0 ± 2.7	32.2 ± 2.2†††	33.2 ± 1.9‡‡‡
WBCs, 103/μL	4.4 ± 2.4	17.3 ± 5.4	8.4 ± 2.9**	8.1 ± 6.3	17.0 ± 8.0††	16.9 ± 6.0‡
Neutrophils, 103/μL	0.8 ± 0.5	3.7 ± 1.5	1.2 ± 0.3	1.1 ± 0.5	3.3 ± 1.4†††	3.2 ± 1.2‡‡
Lymphocytes, 103/μL	3.3 ± 1.8	12.5 ± 5.5	6.6 ± 2.4**	6.3 ± 5.8	12.4 ± 6.5†	12.6 ± 5.0
Monocytes, 103/μL	0.2 ± 0.2	0.9 ± 0.3	0.5 ± 0.2*	0.5 ± 0.1	1.2 ± 0.5†††	1.1 ± 0.4‡
Platelets, 103/μL	682 ± 100	727 ± 125	712 ± 109	716 ± 62	770 ± 132	795 ± 118

No statistically significant differences were observed in hematologic profile between the following groups: BERK vs BERK^BM/IgG, WT^BM/IgG vs WT^BM/1H1, and BERK^BM/IgG vs BERK^BM/1H1.

RBCs indicates red blood cells; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; NA, not applicable; MCHC, mean corpuscular hemoglobin concentration; and WBCs, white blood cells.

Statistical difference in hematologic parameters between WT and WT^BM/IgG mice: *P < .05; **P < .01; and ***P < .001.

Statistical difference in hematologic parameters between WT^BM and BERK^BM mice treated with control rat IgG antibody: †P < .05; ††P < .01; and †††P < .001.

Statistical difference in hematologic parameters between WT^BM and BERK^BM mice treated with rat anti–mouse TF antibody: ‡P < .05; ‡‡P < .01; and ‡‡‡P < .001.