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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Microvasc Res. 2012 Jun 5;84(2):155–160. doi: 10.1016/j.mvr.2012.05.009

Figure 4. Kinase pathways are involved in the peroxide-induced increase in PLGF mRNA.

Figure 4

Human CASMC were treated with a single dose of H2O2 (50 µM) in the presence of a p38 MAPK inhibitor (10 µM), JNK inhibitor (10 µM) or ERK1/2 inhibitor (10 µM) for 8 h. All three kinase inhibitors significantly reduced the H2O2-induced increase in PLGF mRNA, compared to treatment with H2O2 alone (*p<0.05, n=3; #p<0.05, H2O2 treated vs. untreated).